The Zambezi River (also spelled Zambeze and Zambesi) is the fourth-longest river in Africa, the longest east-flowing river in Africa and the largest flowing into the Indian Ocean from Africa. Its drainage basin covers 1,390,000 km² (540,000 sq mi), slightly less than half of the Nile's. The 2,574-kilometre-long (1,599 mi) river rises in Zambia and flows through eastern Angola, along the north-eastern border of Namibia and the northern border of Botswana, then along the border between Zambia and Zimbabwe to Mozambique, where it crosses the country to empty into the Indian Ocean.

The Zambezi's most noted feature is Victoria Falls. Its other falls include the Chavuma Falls at the border between Zambia and Angola, and Ngonye Falls near Sioma in western Zambia.

The two main sources of hydroelectric power on the river are the Kariba Dam, which provides power to Zambia and Zimbabwe, and the Cahora Bassa Dam in Mozambique, which provides power to Mozambique and South Africa. Additionally, two smaller power stations are along the Zambezi River in Zambia, one at Victoria Falls and the other in Zengamina, near Kalene Hill in the Ikelenge District.